TB-500 refers to the active fragment of the naturally occurring protein Thymosin Beta-4. It is one of the most abundant intracellular peptides in mammalian tissue and plays a central role in actin dynamics. It has been studied for its role in wound healing, angiogenesis, and cardiac tissue repair in animal models.
Sequence
LKKTETQ
Molecular Weight
~881.0 g/mol (fragment)
Half-life (Preclinical)
Estimated days (full TB-4); shorter for fragment
Mechanism
Actin sequestration; promotion of cell migration, angiogenesis, and anti-inflammatory signaling
Multiple animal studies have demonstrated accelerated healing of cardiac muscle, tendon, and skin wounds. Cardiac applications have been of particular scientific interest, with publications suggesting protective effects following ischemic injury in rodents.
Research Strengths
Strong rodent research base
Multi-system healing activity
Good tolerability profile in animals
Endogenous peptide origin
Limitations & Considerations
Expensive raw material
Complex storage requirements
Human data absent
This information is for research reference only. TB-500 is a Research Use Only (RUO) compound not approved for human or veterinary use. This does not constitute medical advice.