Ipamorelin is a pentapeptide GH secretagogue notable for its high selectivity — it stimulates GH release with minimal effect on cortisol and prolactin compared to other GHRPs. This selectivity makes it a preferred tool in research contexts where isolated GH axis effects are desired.
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Molecular Weight
711.86 g/mol
Half-life (Preclinical)
~2 hours (rodent)
Mechanism
Selective GHS-R1a agonist; GH secretagogue with minimal cortisol/prolactin effect
Storage
-20°C lyophilized
Solubility
Bacteriostatic water
Research Summary
Ipamorelin has been studied in rodent and porcine models for effects on body composition, bone density, and GH pulse characteristics. It is often combined with GHRH analogs to study synergistic amplification of GH release.
Research Strengths
High receptor selectivity
Minimal cortisol/prolactin stimulation
Good tolerability in animal models
Useful for clean GH axis studies
Limitations & Considerations
Less potent than GHRP-2 alone
Short half-life requires frequent dosing in protocols
Limited human studies
This information is for research reference only. Ipamorelin is a Research Use Only (RUO) compound not approved for human or veterinary use. This does not constitute medical advice.