GH Secretagogue

GHRP-2

Growth Hormone Releasing Peptide-2

GHRP-2 — Research Overview

GHRP-2 is a synthetic hexapeptide that acts as a potent agonist at the ghrelin receptor (GHS-R1a), stimulating pulsatile growth hormone release from the anterior pituitary. It is among the most potent GH secretagogues studied in preclinical research.

Sequence
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
Molecular Weight
817.94 g/mol
Half-life (Preclinical)
~30 minutes (rodent)
Mechanism
Ghrelin receptor (GHS-R1a) agonist; stimulates pituitary GH secretion
Storage
-20°C lyophilized
Solubility
Bacteriostatic water

Research Summary

GHRP-2 has been the subject of numerous studies examining pituitary function, GH pulse dynamics, and IGF-1 modulation. It also stimulates cortisol and prolactin to a moderate degree. It is frequently co-administered with CJC-1295 in research protocols to examine synergistic GH release.

Research Strengths
  • Potent and well-characterized
  • Extensive published research
  • Useful as a research tool peptide
  • Predictable dose-response in animals
Limitations & Considerations
  • Stimulates cortisol and prolactin
  • Very short half-life
  • Must be kept cold post-reconstitution
This information is for research reference only. GHRP-2 is a Research Use Only (RUO) compound not approved for human or veterinary use. This does not constitute medical advice.