Epithalon is a synthetic tetrapeptide analog of Epithalamin, a natural polypeptide extract of the pineal gland. It is of significant interest in longevity research due to its purported ability to activate telomerase enzyme in human somatic cells.
Sequence
Ala-Glu-Asp-Gly
Molecular Weight
390.35 g/mol
Half-life (Preclinical)
Short; minutes to hours
Mechanism
Telomerase activation; regulation of pineal gland function and melatonin secretion
Storage
-20°C lyophilized
Solubility
Water
Research Summary
In vitro research has demonstrated telomerase activation in human fetal fibroblasts. Animal studies have reported lifespan extension. Long-term human studies of limited scale have been published by Russian researchers.
Research Strengths
Telomerase activation in vitro documented
Simple tetrapeptide — easy to synthesize
Animal lifespan data published
Pineal regulation research interest
Limitations & Considerations
Most data from single research group
Mechanism debated
Very short half-life
Human data very limited
This information is for research reference only. Epithalon is a Research Use Only (RUO) compound not approved for human or veterinary use. This does not constitute medical advice.