BPC-157 is a synthetic 15-amino-acid peptide fragment derived from a protective gastric protein. In preclinical animal studies, it has demonstrated remarkable activity in accelerating healing of soft tissues, tendons, ligaments, and gastrointestinal tract injuries. It appears to act by upregulating growth factor pathways including VEGF, promoting angiogenesis and fibroblast migration.
Sequence
GEPPPGKPADDAGLV
Molecular Weight
1,419.53 g/mol
Half-life (Preclinical)
~4 hours (subcutaneous, murine)
Mechanism
Upregulation of growth factor signaling (VEGF, EGF, FGF); modulation of nitric oxide system
Storage
-20°C lyophilized; stable 24 months
Solubility
Sterile water or bacteriostatic water
Research Summary
Published research (predominantly in rodent models) has examined BPC-157's effects on tendon-to-bone healing, inflammatory bowel models, and wound closure. A notable series of studies from Croatian researchers has documented activity across multiple organ systems. No human clinical trials have been published as of 2025.
Research Strengths
Extensive preclinical literature
Stable in lyophilized form
Well-characterized mechanism
Multiple administration routes studied
Limitations & Considerations
No human clinical trials published
Mechanism not fully elucidated
High batch-to-batch sensitivity in assays
This information is for research reference only. BPC-157 is a Research Use Only (RUO) compound not approved for human or veterinary use. This does not constitute medical advice.